Solution:
Consider the set S0 equivalent to S that contains 3. If it contains 5 but not 7, then the set S1 equivalent to S containing 7 must contain 9, which is not prime. Likewise, S0 cannot contain 7 but not 5, because then the set S1 containing 5 must contain 9. Suppose S0 contains 3,5, and 7. Then any other set S1 of the tiling contains elements p,p+2, and p+4. But not all of these can be prime, because one of them is divisible by 3. Finally, suppose S0 contains 3 and has second-smallest element p>7. Then the set S1 containing 5 does not contain 7 but does contain p+2, and the set S2 containing 7 contains p+4. But as before, not all of p,p+2, and p+4 can be prime. Therefore S has no second-smallest element, so it has only one element.