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Which of these numbers is neither a multiple of 3, nor a multiple of 4?

(A) $16$ (B) $21$ (C) $28$ (D) $34$ (E) $45$

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Source: UK Mathematics Trust, licensed © UK Mathematics Trust; past papers published free at ukmt.org.uk. Statement reproduced verbatim; metadata (topic, difficulty, ordering) added by this project. Solutions are the publisher's, linked not copied.