It is evident that
∣(a−b)(b−c)(c−d)(d−a)∣≤4abcd⟺
ab(a−b)2⋅bc(b−c)2⋅cd(c−d)2⋅da(d−a)2≤161.(∗)
Note that
ab(a−b)2≤21.(1)
Indeed, we have
ab(a−b)2≤21⇔2(a−b)2≤ab⇔2(ba)2−5(ba)+2≤0⇔2(ba−2)(ba−21)≤0.
The last inequality holds since a,b∈[1,2].
Similarly we have
bc(b−c)2≤21,(2)
cd(c−d)2≤21,(3)
da(d−a)2≤21.(4)
Multiplying (1), (2), (3), (4), we obtain the required inequality (*).
Note that the equality occurs when
{(a,b,c,d)=(2,1,2,1),(1,2,1,2)}.