Solution:
If we multiply the given equation and inequality (x>0,y>0,z>0), we have
(y4x+xy)+(xz+z9x)+(y4z+z9y)≤22
From AM-GM we have
y4x+xy≥4,xz+z9x≥6,y4z+z9y≥12
Therefore
22≤(y4x+xy)+(xz+z9x)+(y4z+z9y)
Now from (1) and (3) we get
(y4x+xy)+(xz+z9x)+(y4z+z9y)=22
which means that in (2), everywhere equality holds i.e. we have equality between means, also x+y+z=12.
Therefore y4x=xy, xz=z9x and, as x>0,y>0,z>0, we get y=2x, z=3x. Finally if we substitute for y and z, in x+y+z=12, we get x=2, therefore y=2⋅2=4 and z=3⋅2=6.
Thus the unique solution is (x,y,z)=(2,4,6).